Structure and function of the nuclear pore complex.
نویسنده
چکیده
Javier Fernandez-Martinez1,7, Seung Joong Kim2,7, Yi Shi3,7, Paula Upla4,7, Riccardo Pellarin2,6,7, Michael Gagnon5, Ilan E. Chemmama2, Junjie Wang3, Ilona Nudelman1, Wenzhu Zhang3, Rosemary Williams1, William J. Rice4, David L. Stokes4, Daniel Zenklusen5, Brian T. Chait3,*, Andrej Sali2,*, and Michael P. Rout1,* 1Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY10065, USA
منابع مشابه
Sensitivity Analysis of the Effect of Pore Structure and Geometry on Petrophysical and Electrical Properties of Tight Media: Random Network Modeling
Several methodologies published in the literature can be used to construct realistic pore networks for simple rocks, whereas in complex pore geometry formations, as formed in tight reservoirs, such a construction still remains a challenge. A basic understanding of pore structure and topology is essential to overcome the challenges associated with the pore scale modeling of tight porous media. A...
متن کاملContribution of Electron Microscopy to the Study of the Nuclear Pore Complex Structure, Composition, and Function
In interphase eukaryotic cells, the nucleus is separated from the cytoplasm by a double nuclear membrane system called the nuclear envelope. The nuclear envelope enables the two cell compartments to have their distinct composition, and separates the genetic machinery from protein synthesis. Molecular exchange between the nucleus and the cytoplasm, however, is essential for keeping eukaryotic ce...
متن کاملCaspases target only two architectural components within the core structure of the nuclear pore complex.
Caspases were recently implicated in the functional impairment of the nuclear pore complex during apoptosis, affecting its dual activity as nucleocytoplasmic transport channel and permeability barrier. Concurrently, electron microscopic data indicated that nuclear pore morphology is not overtly altered in apoptotic cells, raising the question of how caspases may deactivate nuclear pore function...
متن کاملThe nuclear pore complex--structure and function at a glance.
Nuclear pore complexes (NPCs) are indispensable for cell function and are at the center of several human diseases. NPCs provide access to the nucleus and regulate the transport of proteins and RNA across the nuclear envelope. They are aqueous channels generated from a complex network of evolutionarily conserved proteins known as nucleporins. In this Cell Science at a Glance article and the acco...
متن کاملDeep Insight Section
In this review we summarize the structure and function of the nuclear pore complex (NPC). Special emphasis is put on recent findings which reveal the NPC as a dynamic structure in the context of cellular events like nucleocytoplasmic transport, cell division and differentiation, stress response and apoptosis. Evidence for the involvement of nucleoporins in transcription and oncogenesis is discu...
متن کاملStructure, dynamics and function of nuclear pore complexes.
Nuclear pore complexes are large aqueous channels that penetrate the nuclear envelope, thereby connecting the nuclear interior with the cytoplasm. Until recently, these macromolecular complexes were viewed as static structures, the only function of which was to control the molecular trafficking between the two compartments. It has now become evident that this simplistic scenario is inaccurate a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Annual review of cell biology
دوره 8 شماره
صفحات -
تاریخ انتشار 1992